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A Critical Overview of a Primary Mcb Paper: a Wnt–Axin2–Gsk3Β Chute Regulates Snail1 Activity in Breast Cancer Cellular material

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 A Critical Overview of a Primary Mcb Paper: a WntAxin2Gsk3 Chute Regulates Snail1 Activity in Breast Cancer Skin cells

A vital review of a primary MCB paper: A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in cancer of the breast cells

Speculation:

By collection of available proof, Yook ain al suggest that through hyper-active Wnt signalling, β-catenin-T-Cell factor [TCF] activates epithelial mesenchymal transition [EMT] in man breast cancer skin cells. They then hypothesise that canonical Wnt signalling can result in tumour cell dedifferentiation and tissue-invasive activity -- through an Axin2-dependent pathway. They will aim to show this can occur by the stabilisation of the zinc transcription element, Snail1 that they state plays an crucial regulation function of EMT programmes.

Comment: The context of the experiment including present-day clinical evidence and present-day understanding was well established on the onset. However , the opening passage is a to some degree convoluted mixture of the author's experimental aims supported by a multitude of scientific details. It's hard to detect which of those were deduced prior-to and which post- their experimentation. A description with the experiments and hypotheses getting tested: such as controls used, number of trial and error replicates and the statistical research used. A critique of how effectively your data is presented. Finally, does the experimental info really display what the authors say it will?

Figure one particular is subdivided into 4 panels: 1a-1d – every single visually documenting results of experiments examining particular concerns that collectively challenged the hypothesis to evaluate its quality.

Number 1a reveals the confocal microscopy effects of mock-transfected fluorescently-labelled MCF-7 cells and Wnt revealing tumour MCF-7 cells classy on the vascularised epithelial-stromal cells of the chorioallantoic membrane [CAM] of 11-day-old chick embryos. The authors hypothesised the mock-transferred MCF-7 cells would remain confined to the upper CAM surface as they were unable to convey a tissue-invasive phenotype because...

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